OsteGro - Aziyo
Aziyo OsteGro Product Logo

For Bone Repair

Designed to Support New Bone Growth in Spine and Orthopedic Surgical Procedures.1

OsteGro Bone Matrices

OsteGro V Osteo Viable Matrix is the Viable Bone Matrix (VBM) product in the OsteGro family. It is comprised of cancellous bone particles with preserved cells combined with demineralized cortical particles and fibers all processed via Aziyo’s proprietary gentle VBM processes.

OsteGro Allograft Bone Matrix, the second product in this family, is a sterile bone matrix comprised of cancellous particles and demineralized cortical fibers.

The Aziyo Advantage

Aziyo has developed a proprietary processing methodology for human tissue that creates VBM allografts that contain the scaffold, growth factors and cells required for regeneration. Aziyo has designed the process to protect native elements of bone, including growth factors and osteoprogenitor cells that are known to be biologically active and critical for successful bone formation.2

Person with blue gloves molding OsteGro

Bone Regeneration Elements Preserved.

The 3 Essential Elements

Diagram outlining the main elements of bone regeneration
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Osteogenesis

Cells capable of differentiating to bone cell lineage and synthesizing bone matrices.

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Osteoinductivity

Bioactive growth factors capable of inducing osteoblast differentiation, growth and maturation.

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Osteoconductivity

Scaffolds cued as substrate for supporting cellular activities and bone matrix organization.

Person sitting on the ground tying their shoe

Optimized Cellular Health to Improve Osteogenesis.

Typical VBM tissue processes may include steps that can increase apoptosis (cell death) and reduce osteogenic potential.3,4,5 Aziyo’s proprietary gentle VBM process minimizes damaged, apoptotic (dying) cells resulting in VBMs that proliferate faster than competitive products, which is associated with greater osteogenic potential.2

Industry standard methods for cell counting cannot distinguish between living and dying (apoptotic) cells in the final product, leading to overestimates in the viable cell content of bone matrices. Aziyo has developed a measurement system which can demonstrate the reduction in apoptotic cell content of its products.2

Substantially Fewer Apoptotic Cells 2

chart with arrow and boxes showing that Aziyo ABM has Fewer Apoptotic Cells

Faster Rate of Cell Proliferation vs. Control1

A data graph showing a line increasing from left to right

Optimized Osteoinductivity.

Demonstrated osteoinductivity based on Aziyo’s proprietary demineralization process.2

Bioactivity: Aziyo VBM Demonstrates Osteoinductivity in Vivo

The body's response to Viable Bone Matrix

Aziyo Process Yields Higher BMP-2 and BMP-7 Levels Than a Control2

Data Chart with orange boxes and arrows

Aziyo’s proprietary processing also addresses the need for optimizing the osteoinductivity of cellular bone matrices. Processing parameters are designed to maximize availability of the natural growth factors in bone resulting in bone formation.1

close up illustration of Cancellous bone matrix

Photo: Cancellous bone matrix for illustration purposes only.

Naturally Osteoconductive.

Aziyo’s proprietary VBM processing produces a natural 3-dimensional scaffold for bone formation (conduction) at the implant site.2

Optimized Handling.

Unique handling properties support ease of placement at implant site.

Blue gloves holding a round tan piece of viable bone matrix

Shape

Physician forming the viable bone matrix

Form

Physician pulling apart a molded OsteGro sample

Mold

Physician holding a piece of molded viable bone matrix

Implant

Product Specifications

Inter-operative Ease of Use
  • No decanting decreases prep and thaw time
  • Thaws in 5-15 minutes*
  • No rinsing prior to implantation

* dependent on allograft volume

Sizing and Ordering Information

Product Numbers are for U.S. only.

OsteGro V Osteo Viable Bone Matrix is offered frozen in 1cc, 2cc, 5cc and 10cc vials and, once thawed, requires no additional steps for implantation.

wdt_ID Product Number Name Size
1 OSGV-0001 OsteGro V Osteo Viable Matrix 1cc
2 OSGV-0002 OsteGro V Osteo Viable Matrix 2cc
3 OSGV-0005 OsteGro V Osteo Viable Matrix 5cc
4 OSGV-0010 OsteGro V Osteo Viable Matrix 10cc

Download IFU

IFU for U.S. only.

Interested in OsteGro V?

Learn About OsteGro V Today!

For more information on OsteGro V, contact customer service at 800-922-3100, or fill out this form.

1. Aziyo Biologics Data on File
2. Eder et al. Eur Spine J. 2011. 20.
3. Li et al. J Orthopaedic Res. 1999. 17 (6).
4. Dolan et al. J. R. Soc Interface. 2012. 9.

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