Aziyo CanGaroo Product Logo

For the Secure Implantation of CIEDs

Reduce Complications Associated  with Cardiovascular Implantable Electronic Devices.

CanGaroo reduces scarring and promotes healthy controlled healing.1,2,3

Make patient care more predictable and manageable with the CanGaroo Envelope. CanGaroo regulates the biologic healing response post implant, reduces inflammation, and mitigates excessive scar tissue formation and the associated complications.1,2,3

CanGaroo is an extracellular matrix that creates a hospitable environment for host cells to migrate and initiate tissue remodeling, stabilizing the device in healthy vascularized tissue.2

CanGaroo Envelope Product Animation

Representative product shown.

The First. The Only.

The CanGaroo is the first and only natural biologic envelope designed to help reduce complications with CIED implants.

Aziyo CanGaroo Product Benefits and Features Diagram

An extracellular matrix derived from porcine small intestine submucosa, the CanGaroo Envelope regulates the biologic healing response to decrease inflammation and stimulate formation of healthy tissue.2,3 It’s soft and pliable and easily conforms to the shape of the implantable device.

Grandfather holding grandchild

Physician Trust.

More than 1,200 institutions trust Aziyo products for their patients. Physicians, like Dr. Koide use CanGaroo to reduce complications associated with pocket scarring that could lead to difficult change-outs and increase risk for infection.4,5

CanGaroo. For Life.

CanGaroo restores the natural anatomy post implant.1,2 It encourages healthy tissue growth by creating a hospitable environment for host cells to migrate and propagate into the ECM bio scaffold.1,2,3 The new healthy tissue secures and can protect the implanted CIED for the life of the device. Using a CanGaroo at implant is simple and helps make patient care more predictable.

Avoid Scar Tissue.

Dr. Niuton S. Koide MD, FACC
Cardiac Electrophysiologist in Las Vegas, Nevada

“We recently had a case where we implanted a pacemaker and used the CanGaroo Envelope. Three to four months later we had to reopen the pocket to upgrade the device. It was really exciting because everyone in the room wanted to see how the pocket had healed. We saw healthy viable tissue around the pacemaker and no fibrotic capsule or CanGaroo Envelope. It was completely replaced by healthy tissue. We all learned that yes, the product does work.”

Asad Mohammed, DO
Mount Sinai Hospital, New York

ECM. How It Works.

The Body’s Reaction 

When a device or foreign material is implanted in a patient, their immune response either integrates and remodels it into healthy tissue or induces prolonged inflammation that may result in the formation of fibrotic tissue. While the former is more desirable, the latter is too common.

Stephen F. Badylak, DVM, PhD, MD
Deputy Director, McGowan Institute for Regenerative Medicine, University of Pittsburgh


Minimize Inflammation

To minimize inflammation (and the associated complications) and achieve optimal tissue remodeling outcomes in patients CanGaroo is created using two multilaminate sheets of decellularized, non-crosslinked, lyophilized SIS. SIS ECM is associated with biologic activity such as recruitment of endogenous stem/progenitor cells and modulation of the host response to injury resulting in pro-remodeling, anti-inflammatory tissue growth.3


Healthy Tissue Growth

SIS derived ECM is a biomaterial rich in growth factors and structural proteins.3,6,7 Useful in multiple clinical applications, SIS remodels into healthy, site-specific tissue that stimulates healthy tissue growth and eliminates scarring.2,3,6,7

Learn More About ECM.

Watch our informational video to learn more about Extracellular Matrix.

Learn About CanGaroo.

To learn more about the CanGaroo Envelope contact your area sales representative or contact us.

1. Aziyo Biologics Data on File
2. Based on preclinical data on file
3. Dziki JL, et al. J Biomed Mater Res A. 2017;105(1):138–147. 
4. Maytin M, et al. Journal of Innovations in Cardiac Rhythm Management. 2015;6(11):2173-2177. 
5. Wilkoff BL. Tex Heart Inst J. 2011;38(4):353–354.
6. Badylak S, et al. J Surg Res. 2002 Apr;103(2):190-202.
7. Brennan EP, et al. Tissue Eng. 2006;12(10):2949-2955.


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