Electrophysiologist - Aziyo

Reduce Future Complications Associated with Pocket Scarring.

Secure your devices and make future care more predictable with the extracellular matrix that remodels into healthy vascularized tissue.4

Reduce Risk. Naturally.

We help Electrophysiologists reduce complications.

Reduce daily complications and risk while making patient care more predictable and manageable. CanGaroo helps orchestrate a controlled healing response, promotes devices stabilization and mitigates excessive scar tissue formation—and the associated complications.3,4,5

“The host response to biomaterials is a critical determinant of their success or failure in tissue-repair applications.”

Dziki JL, et al. J Biomed Mater Res A. 2017;105(1):138–147.

How Aziyo Helps.

Common complications CanGaroo targets.

Infection associated to severe pocket scarring (systemic & local) 1,2

CanGaroo mitigates scar tissue formation that could result in a calcified fibrotic capsule.4,5 Scar tissue may be a nidus for bacteria and scar tissue severity has been associated with higher rates of related infection.1,2

Inflammation associated with pocket scarring (acute & chronic) 2

SIS ECM alters the biologic healing response associated with inflammation to a healing response that modulates inflammation and expresses a macrophage phenotype that is pro-remodeling.3,9,10

Difficult lead extractions or pocket revisions due to scarring 2

A vascularized pocket with minimal scar tissue may facilitate lead mobilization in the pocket leading to easier changeout and CIED explant.4

Procedural times related to excessive pocket scarring 2

CanGaroo mitigates the formation of scar tissue, which may reduce time associated with device explants due to tedious dissection of leads coiled in the pocket.4,5

Calcified fibrotic capsule

CanGaroo remodels into soft flexible vascularized tissue.4 Mitigating a calcified fibrotic capsule may eliminate the need to perform a capsulectomy or other associated complications.

Device erosion

CanGaroo remodels into healthy tissue and stabilizes the device.4 Patients with thin skin may be at risk for erosion and discomfort and may benefit from an added layer of tissue that secures the device.

Device migration
CanGaroo is indicated to stabilize CIEDs. Long-term it stabilizes the CIED with native vascularized tissue.4

ECM. How It Works.

The Body’s Reaction 

When a device or foreign material is implanted in a patient, their immune response either integrates and remodels it into healthy tissue or induces prolonged inflammation that may result in the formation of fibrotic tissue. While the former is more desirable, the latter is too common.

Stephen F. Badylak, DVM, PhD, MD
Deputy Director, McGowan Institute for Regenerative Medicine, University of Pittsburgh

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Minimize Inflammation

To minimize inflammation (and the associated complications) and achieve optimal tissue remodeling outcomes in patients CanGaroo is created using two multilaminate sheets of decellularized, non-crosslinked, lyophilized SIS. SIS ECM is associated with biologic activity such as recruitment of endogenous stem/progenitor cells and modulation of the host response to injury resulting in pro-remodeling, anti-inflammatory tissue growth.3

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Healthy Tissue Growth

SIS derived ECM is a biomaterial rich in growth factors and structural proteins.3,9,10 Useful in multiple clinical applications, SIS remodels into healthy, site-specific tissue that stimulates healthy tissue growth and eliminates scarring.3,4,9,10

Phases of ECM Guided Wound Healing.

An image that shows cellular inflammation

Inflammation

Inflammation involving M1 macrophages is an inherent component of healing. However, prolonged M1 macrophage function can cause chronic inflammation and lead to fibrosis and scarring. The presence of SIS ECM promotes a shift from M1 to a pro-remodeling, anti-inflammatory M2 phenotype.6

An image showing proliferation in the body

Proliferation

Concurrent with the inflammatory phase, in the proliferation phase fibroblasts populate the SIS ECM through attaching and proliferating.7 This stage is also marked by angiogenesis and epithelization which forms healthy vascularized tissue.7 

An image of remodeling within the body

Tissue Remodeling

As the SIS ECM is broken down and absorbed, the number of fibroblasts and macrophages in the matrix declines over time.7 Matrix turnover ultimately slows and eventually stops, ending angiogenesis.6 Scaffold remodeling is complete when metabolic activity stabilizes and the newly regenerated tissue becomes fully functional.7,8

Learn About CanGaroo.

Make patient care more predictable and manageable.

Learn how you can regulate your patients’ biologic healing response post implant, reduce inflammation, and mitigate excessive scar tissue formation and thus the associated complications with CanGaroo.

Interested in CanGaroo?

Try CanGaroo Envelope Today!

To schedule a product demo or request an in-service for a product evaluation contact us today.

1. Wilkoff BL. Infections associated with cardiac implantable electronic devices are misunderstood. Tex Heart Inst J. 2011;38(4):353–354.
2. Maytin M., et al. Journal of Innovations in Cardiac Rhythm Management. 2015;6(11):2173 – 2177. doi:10.19102/icrm.2015.061101.
3. Dziki JL, et al. J Biomed Mater Res A. 2017;105(1):138–147.
4. Based on pre-clinical data on file
5. Aziyo Biologics Data on File
6. Londono, R., et al. Ann Biomed Eng, 2015. 43(3): p. 577-92.
7. Turner, M.D., et al., Biochim Biophys Acta, 2014. 1843(11): p. 2563-2582.
8. Tonnesen, M.G., et al. J Investig Dermatol Symp Proc, 2000. 5(1): p. 40-6.
9. Badylak S et al. J Surg Res. 2002 Apr;103(2):190-202.
10. Brennan EP, et al. Tissue Eng. 2006;12(10):2949-2955. doi:10.1089/ten.2006.12.2949

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