Biologic Solutions for Cardiac and Vascular Surgeons.

Make patient care more predictable and manageable with the extracellular matrix (ECM) that remodels into healthy, site-specific tissue.3,4,5,6,10,11

A Cardiac or Vascular Surgeon In the operating room

Reduce Risk. Naturally.

We help Cardiac & Vascular surgeons repair tissue with fewer complications.

Reducing complications and risk may make patient care more predictable and manageable. An extracellular matrix derived from porcine small intestine submucosa (SIS), our bioscaffold regulates the biologic healing response to decrease inflammation and stimulate formation of healthy tissue. 2,6

“The host response to biomaterials is a critical determinant of their success or failure in tissue-repair applications.”

Dziki JL, et al. J Biomed Mater Res A. 2017;105(1):138–147.

How Aziyo Helps.

Stephen F. Badylak, DVM, PhD, MD
Deputy Director, McGowan Institute for Regenerative Medicine, University of Pittsburgh

ECM regulates healing.

When sutured to viable tissue, Aziyo ECM products have a potential to remodel into site specific tissue.2,6,10,11 After implantation, SIS ECM remodels and reduces inflammation and stimulates angiogenesis.6,10,11 The transformation of SIS ECM into site-specific tissue may offer long-term benefits including facilitating reoperation if needed.4,5 Learn how SIS ECM reduces remodels into site-specific tissue engineering expert Dr. Badylak.

ECM. How It Works.

The Body’s Reaction 

When a device or foreign material is implanted in a patient, their immune response either integrates and remodels it into healthy tissue or induces prolonged inflammation that may result in the formation of fibrotic tissue. While the former is more desirable, the latter is too common.

Stephen F. Badylak, DVM, PhD, MD
Deputy Director, McGowan Institute for Regenerative Medicine, University of Pittsburgh

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Minimize Inflammation

To minimize inflammation (and the associated complications) and achieve optimal tissue remodeling outcomes in patients, we’ve constructed ProxiCor PC, ProxiCor CTR and VasCure using multilaminate sheets of decellularized, non-crosslinked, lyophilized small intestinal submucosa (SIS). SIS ECM is associated with biologic activity such as recruitment of endogenous stem/progenitor cells and modulation of the host response to injury resulting in pro-remodeling, anti-inflammatory tissue growth.6

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Healthy Tissue Growth

SIS derived Extracellular Matrix (ECM) is a biomaterial rich in growth factors and structural proteins.6,10,11 Useful in multiple clinical applications, SIS remodels into healthy, site-specific tissue that stimulates healthy tissue growth and inhibits excessive scarring.2,4,5,6,10,11

Phases of ECM Guided Wound Healing.

An image that shows cellular inflammation

Inflammation

Inflammation involving M1 macrophages is an inherent component of healing. However, prolonged M1 macrophage function can cause chronic inflammation and lead to fibrosis and scarring. The presence of SIS ECM promotes a shift from M1 to a pro-remodeling, anti-inflammatory M2 phenotype.7

An image showing proliferation in the body

Proliferation

Concurrent with the inflammatory phase, in the proliferation phase fibroblasts populate the SIS ECM through attaching and proliferating.8 This stage is also marked by angiogenesis and epithelization which forms healthy vascularized tissue.8

An image of remodeling within the body

Tissue Remodeling

As the SIS ECM is broken down and absorbed, the number of fibroblasts and macrophages in the matrix declines over time.7 Matrix turnover ultimately slows and eventually stops, ending angiogenesis.6 Scaffold remodeling is complete when metabolic activity stabilizes and the newly regenerated tissue becomes fully functional.7,8

Patient Success Story.

Lori Wisniewski

Cardiac surgery patient (ProxiCor CTR).

The surgery was performed July 11, 2011 and at the end of September I was able to complete a triathlon! About 6 months after the surgery, she had a routine transesophageal echo where it was difficult to discern a difference between the ProxiCor CTR bioscaffold and the adjacent heart tissue. No further tests have been required.

Image of a blond woman on a walk in the forrest

Cardiac & Vascular Products.

A colored image of the Aziyo ProxiCor product logo
ProxiCor PC

ProxiCor for Pericardial Closure

A colored image of the Aziyo ProxiCor product logo
ProxiCor CTR

ProxiCor for Cardiac Tissue Repair

Color image of Aziyo VasCure product logo
VasCure

VasCure for Vascular Repair

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1. Aziyo Biologics Data on File
2. Based on pre-clinical data on file.
3. Rego A, et al. J Cardiothorac Surg. 2019;14(1):61. Published 2019 Mar 15. doi:10.1186/s13019-019-0871-5
4. Shell D et al. Ann Surg. 2005 Jun;241(6):995-1001; discussion 1001-4.
5. Gerdisch M et al. J Thorac Cardiovasc Surg. 2014 Oct;148(4):1370-8.
6. Dziki JL, et al. J Biomed Mater Res A. 2017;105(1):138–147
7. Londono, R., et al. Ann Biomed Eng, 2015. 43(3): p. 577-92.
8. Turner, M.D., et al., Biochim Biophys Acta, 2014. 1843(11): p. 2563-2582.
9. Tonnesen, M.G., et al. J Investig Dermatol Symp Proc, 2000. 5(1): p. 40-6.
10. Badylak S et al. J Surg Res. 2002 Apr;103(2):190-202.
11. Brennan EP, et al. Tissue Eng. 2006;12(10):2949-2955. doi:10.1089/ten.2006.12.2949

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